Ontology highlight
ABSTRACT:
SUBMITTER: Sacher M
PROVIDER: S-EPMC1170591 | biostudies-other | 1998 May
REPOSITORIES: biostudies-other
Sacher M M Jiang Y Y Barrowman J J Scarpa A A Burston J J Zhang L L Schieltz D D Yates J R JR Abeliovich H H Ferro-Novick S S
The EMBO journal 19980501 9
We previously identified BET3 by its genetic interactions with BET1, a gene whose SNARE-like product acts in endoplasmic reticulum (ER)-to-Golgi transport. To gain insight into the function of Bet3p, we added three c-myc tags to its C-terminus and immunopurified this protein from a clarified detergent extract. Here we report that Bet3p is a member of a large complex ( approximately 800 kDa) that we call TRAPP (transport protein particle). We propose that TRAPP plays a key role in the targeting a ...[more]