Aberration of porphyrin metabolism in iron-deficient anaemic rats.
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ABSTRACT: Iron-deficient rats excreted greater amounts of 5-aminolaevulinate in urine but the output of porphobilinogen was decreased considerably. In addition, activity of the enzyme 5-aminolaevulinate dehydratase was diminished in bone marrow and liver. The results suggest that in iron deficiency a defect occurs in porphyrin synthesis at the level of porphobilinogen formation.
SUBMITTER: Sharma DC
PROVIDER: S-EPMC1177881 | biostudies-other | 1973 Jul
REPOSITORIES: biostudies-other
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