Ontology highlight
ABSTRACT:
SUBMITTER: Tiziani V
PROVIDER: S-EPMC1378086 | biostudies-other | 1999 Jul
REPOSITORIES: biostudies-other
American journal of human genetics 19990701 1
Cherubism is an autosomal dominant disorder that may be related to tooth development and eruption. It is a disorder of age-related bone remodeling, mostly limited to the maxilla and the mandible, with loss of bone in the jaws and its replacement with large amounts of fibrous tissue. We have used a genomewide search with a three-generation family and have established linkage to chromosome 4p16. Three other families affected with cherubism were also genotyped and were mapped to the same locus. The ...[more]