Ontology highlight
ABSTRACT:
SUBMITTER: Radich JP
PROVIDER: S-EPMC1413797 | biostudies-other | 2006 Feb
REPOSITORIES: biostudies-other
Radich Jerald P JP Dai Hongyue H Mao Mao M Oehler Vivian V Schelter Jan J Druker Brian B Sawyers Charles C Shah Neil N Stock Wendy W Willman Cheryl L CL Friend Stephen S Linsley Peter S PS
Proceedings of the National Academy of Sciences of the United States of America 20060213 8
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease with distinct biological and clinical features. The biologic basis of the stereotypical progression from chronic phase through accelerated phase to blast crisis is poorly understood. We used DNA microarrays to compare gene expression in 91 cases of CML in chronic (42 cases), accelerated (17 cases), and blast phases (32 cases). Three thousand genes were found to be significantly (P < 10(-10)) associated with phase of disease. A c ...[more]