Ontology highlight
ABSTRACT:
SUBMITTER: Farley N
PROVIDER: S-EPMC1430304 | biostudies-other | 2006 Mar
REPOSITORIES: biostudies-other
Farley Nicholas N Pedraza-Alva Gustavo G Serrano-Gomez Diego D Nagaleekar Viswas V Aronshtam Alexander A Krahl Troy T Thornton Tina T Rincón Mercedes M
Molecular and cellular biology 20060301 6
The p38 mitogen-activated protein kinase (MAPK) signaling pathway can be activated by a variety of stress stimuli such as UV radiation and osmotic stress. The regulation and role of this pathway in death receptor-induced apoptosis remain unclear and may depend on the specific death receptor and cell type. Here we show that binding of Fas ligand to Fas activates p38 MAPK in CD8+ T cells and that activation of this pathway is required for Fas-mediated CD8+ T-cell death. Active p38 MAPK phosphoryla ...[more]