Ontology highlight
ABSTRACT:
SUBMITTER: Kramer H
PROVIDER: S-EPMC1460498 | biostudies-other | 1999 Feb
REPOSITORIES: biostudies-other
Genetics 19990201 2
The Drosophila hook gene encodes a novel component of the endocytic compartment. Previously identified hook alleles, which still expressed truncated Hook proteins, affected the accumulation of internalized transmembrane ligands into multivesicular bodies (MVBs). To determine the hook null phenotype, we isolated nine new hook alleles on the basis of their characteristic hooked-bristle phenotype. At least one of these alleles, hk11, is a complete loss-of-function allele. Flies carrying the hk11 al ...[more]