Ontology highlight
ABSTRACT:
SUBMITTER: Millevoi S
PROVIDER: S-EPMC1618107 | biostudies-other | 2006 Oct
REPOSITORIES: biostudies-other
The EMBO journal 20061005 20
The protein factor U2 snRNP Auxiliary Factor (U2AF) 65 is an essential component required for splicing and involved in the coupling of splicing and 3' end processing of vertebrate pre-mRNAs. Here we have addressed the mechanisms by which U2AF 65 stimulates pre-mRNA 3' end processing. We identify an arginine/serine-rich region of U2AF 65 that mediates an interaction with an RS-like alternating charge domain of the 59 kDa subunit of the human cleavage factor I (CF I(m)), an essential 3' processing ...[more]