Ontology highlight
ABSTRACT:
SUBMITTER: Henze UU
PROVIDER: S-EPMC163484 | biostudies-other | 1996 Sep
REPOSITORIES: biostudies-other
Antimicrobial agents and chemotherapy 19960901 9
The Staphylococcus aureus mutant strain PVI selected in vitro for methicillin resistance overexpressed penicillin-binding protein (PBP) 4. In the wild-type parent strain the pbp4 gene was separated by 419 nucleotides from a divergently transcribed abcA locus coding for an ATP-binding cassette transporter. The mutant PVI was shown to have a deletion in the pbp4-abcA promoter region that affected pbp4 transcription but not expression of abcA. Introduction of the pbp4 gene plus the mutant promoter ...[more]