Ontology highlight
ABSTRACT:
SUBMITTER: Louet JF
PROVIDER: S-EPMC1693839 | biostudies-other | 2006 Nov
REPOSITORIES: biostudies-other
Louet Jean-Francois JF Coste Agnès A Amazit Larbi L Tannour-Louet Mounia M Wu Ray-Chang RC Tsai Sophia Y SY Tsai Ming-Jer MJ Auwerx Johan J O'Malley Bert W BW
Proceedings of the National Academy of Sciences of the United States of America 20061110 47
The white adipocyte is at the center of dysfunctional regulatory pathways in various pathophysiological processes, including obesity, diabetes, inflammation, and cancer. Here, we show that the oncogenic steroid receptor coactivator-3 (SRC-3) is a critical regulator of white adipocyte development. Indeed, in SRC-3(-/-) mouse embryonic fibroblasts, adipocyte differentiation was severely impaired, and reexpression of SRC-3 was able to restore it. The early stages of adipocyte differentiation are ac ...[more]