Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC8715676 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Yang Yongjie Y He Yanlin Y Liu Hailan H Zhou Wenjun W Wang Chunmei C Xu Pingwen P Cai Xing X Liu Hesong H Yu Kaifan K Pei Zhou Z Hyseni Ilirjana I Fukuda Makoto M Tong Qingchun Q Xu Jianming J Sun Zheng Z O'Malley Bert W BW Xu Yong Y
Cell reports 20211201 10
The neuroendocrine system coordinates metabolic and behavioral adaptations to fasting, including reducing energy expenditure, promoting counterregulation, and suppressing satiation and anxiety to engage refeeding. Here, we show that steroid receptor coactivator-2 (SRC-2) in pro-opiomelanocortin (POMC) neurons is a key regulator of all these responses to fasting. POMC-specific deletion of SRC-2 enhances the basal excitability of POMC neurons; mutant mice fail to efficiently suppress energy expend ...[more]