Ontology highlight
ABSTRACT:
SUBMITTER: Ghigo JM
PROVIDER: S-EPMC179150 | biostudies-other | 1997 Jun
REPOSITORIES: biostudies-other
Ghigo J M JM Létoffé S S Wandersman C C
Journal of bacteriology 19970601 11
The utilization by Serratia marcescens of heme bound to hemoglobin requires HasA, an extracellular heme-binding protein. This unique heme acquisition system was studied in an Escherichia coli hemA mutant that was a heme auxotroph. We identified a 92-kDa iron-regulated S. marcescens outer membrane protein, HasR, which alone enabled the E. coli hemA mutant to grow on heme or hemoglobin as a porphyrin source. The concomitant secretion of HasA by the HasR-producing hemA mutant greatly facilitates th ...[more]