Ontology highlight
ABSTRACT:
SUBMITTER: Di Fiore B
PROVIDER: S-EPMC2064829 | biostudies-other | 2007 May
REPOSITORIES: biostudies-other
Di Fiore Barbara B Pines Jonathon J
The Journal of cell biology 20070501 3
Ubiquitin-mediated proteolysis is critical for the alternation between DNA replication and mitosis and for the key regulatory events in mitosis. The anaphase-promoting complex/cyclosome (APC/C) is a conserved ubiquitin ligase that has a fundamental role in regulating mitosis and the cell cycle in all eukaryotes. In vertebrate cells, early mitotic inhibitor 1 (Emi1) has been proposed as an important APC/C inhibitor whose destruction may trigger activation of the APC/C at mitosis. However, in this ...[more]