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A pathway and genetic factors contributing to elevated gene expression noise in stationary phase.

ABSTRACT: Previous studies have identified factors associated with transcription and translation efficiency, such as promoter strength and mRNA sequences, that can affect stochasticity in gene expression. Here we present evidence for a pathway and associated genetic factors (namely, the ribosome modulation factor RMF and ppGpp) in Escherichia coli that contribute to heightened levels of gene expression noise during stationary phase. Endogenous cellular mechanisms that globally affect gene expression noise, such as those identified in this study, could provide phenotypic diversity under adverse conditions such as stationary phase.

SUBMITTER: Guido NJ

PROVIDER: S-EPMC2084246 | biostudies-other | 2007 Dec

REPOSITORIES: biostudies-other

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A pathway and genetic factors contributing to elevated gene expression noise in stationary phase.

Guido Nicholas J NJ Lee Philina P Wang Xiao X Elston Timothy C TC Collins J J JJ

Biophysical journal 20070921 11

Previous studies have identified factors associated with transcription and translation efficiency, such as promoter strength and mRNA sequences, that can affect stochasticity in gene expression. Here we present evidence for a pathway and associated genetic factors (namely, the ribosome modulation factor RMF and ppGpp) in Escherichia coli that contribute to heightened levels of gene expression noise during stationary phase. Endogenous cellular mechanisms that globally affect gene expression noise ...[more]

PMID: 17890398

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