A polymorphic microsatellite in the tumor necrosis factor alpha promoter identifies an allele unique to the NZW mouse strain.
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ABSTRACT:
SUBMITTER: Jongeneel CV
PROVIDER: S-EPMC2187966 | biostudies-other | 1990 Jun
REPOSITORIES: biostudies-other
Publications
A polymorphic microsatellite in the tumor necrosis factor alpha promoter identifies an allele unique to the NZW mouse strain.
Jongeneel C V CV Acha-Orbea H H Blankenstein T T
The Journal of experimental medicine 19900601 6
We have amplified a (CA)n:(GT)n microsatellite from the TNF promoters of a panel of mouse strains using the polymerase chain reaction. The length of the microsatellites was polymorphic, with eight alleles observed among 15 inbred strains bearing seven distinct H-2 haplotypes, and four outbred strains. In B10 congenic strains, the TNF allele detected by microsatellite polymorphism segregated with the MHC, and in recombinant haplotypes (NOD, NZW), it segregated with H-2D. The TNF allele found in t ...[more]
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