Ontology highlight
ABSTRACT:
SUBMITTER: Brownlie RJ
PROVIDER: S-EPMC2292226 | biostudies-other | 2008 Apr
REPOSITORIES: biostudies-other
Brownlie Rebecca J RJ Lawlor Kate E KE Niederer Heather A HA Cutler Antony J AJ Xiang Zou Z Clatworthy Menna R MR Floto R Andres RA Greaves David R DR Lyons Paul A PA Smith Kenneth G C KG
The Journal of experimental medicine 20080324 4
FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution ...[more]