The BTB domain of bric a brac mediates dimerization in vitro.
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ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC230577 | biostudies-other | 1995 Jun
REPOSITORIES: biostudies-other
Publications
The BTB domain of bric à brac mediates dimerization in vitro.
Chen W W Zollman S S Couderc J L JL Laski F A FA
Molecular and cellular biology 19950601 6
The gene bric à brac (bab) is required for the proper development of the limbs and ovary in Drosophila melanogaster. bab encodes a BTB domain (also called a POZ domain), an approximately 115-amino-acid conserved motif found primarily in the N termini of zinc finger proteins. In this paper, we show that the BTB domain of bab can mediate protein dimerization in vitro. In addition, we demonstrate that the first 51 amino acids of the bab BTB domain are sufficient for dimerization, and we identify am ...[more]
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