Ontology highlight
ABSTRACT:
SUBMITTER: Kreslavsky T
PROVIDER: S-EPMC2373848 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
Kreslavsky Taras T Garbe Annette I AI Krueger Andreas A von Boehmer Harald H
The Journal of experimental medicine 20080428 5
alphabeta and gammadelta T cell lineages develop in the thymus from a common precursor. It is unclear at which stage of development commitment to these lineages takes place and in which way T cell receptor signaling contributes to the process. Recently, it was demonstrated that strong TCR signals favor gammadelta lineage development, whereas weaker TCR signals promote alphabeta lineage fate. Two models have been proposed to explain these results. The first model suggests that commitment occurs a ...[more]