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Immediate-early transcription over covalently joined genome ends of bovine herpesvirus 1: the circ gene.

ABSTRACT: Herpesvirus genomes are linear molecules in virions. Prior to replication in host cells, they form circular templates by unknown mechanisms. Examining lytic infection with bovine herpesvirus 1, we observed immediate-early transcription over joined genome ends, which suggested that circles are present at the initial stage of infection. Among the transcripts was a spliced immediate-early RNA (1.5 kb) sharing exon 1 with previously described major immediate-early transcripts from the right genome end and exon 2 with a late transcript located near the left genome end. Exon 2 encodes a putative circ-encoded protein with homology to the varicella-zoster virus open reading frame 2 and equine herpesvirus 1 open reading frame 3 products. The novel features reported here for bovine herpesvirus 1 may constitute a more general property of herpesviruses.

SUBMITTER: Fraefel C

PROVIDER: S-EPMC237501 | biostudies-other | 1993 Mar

REPOSITORIES: biostudies-other

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Immediate-early transcription over covalently joined genome ends of bovine herpesvirus 1: the circ gene.

Fraefel C C Wirth U V UV Vogt B B Schwyzer M M

Journal of virology 19930301 3

Herpesvirus genomes are linear molecules in virions. Prior to replication in host cells, they form circular templates by unknown mechanisms. Examining lytic infection with bovine herpesvirus 1, we observed immediate-early transcription over joined genome ends, which suggested that circles are present at the initial stage of infection. Among the transcripts was a spliced immediate-early RNA (1.5 kb) sharing exon 1 with previously described major immediate-early transcripts from the right genome e ...[more]

PMID: 8382298

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