APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.
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ABSTRACT:
SUBMITTER: Reis A
PROVIDER: S-EPMC2435241 | biostudies-other | 2006 May
REPOSITORIES: biostudies-other
Publications
APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.
Reis Alexandra A Chang Heng-Yu HY Levasseur Mark M Jones Keith T KT
Nature cell biology 20060501 5
Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest. ...[more]
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