Ontology highlight
ABSTRACT:
SUBMITTER: Du F
PROVIDER: S-EPMC2516880 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
The EMBO journal 20080717 15
The contractile vacuole (CV) system is the osmoregulatory organelle required for survival for many free-living cells under hypotonic conditions. We identified a new CV regulator, Disgorgin, a TBC-domain-containing protein, which translocates to the CV membrane at the late stage of CV charging and regulates CV-plasma membrane fusion and discharging. disgorgin(-) cells produce large CVs due to impaired CV-plasma membrane fusion. Disgorgin is a specific GAP for Rab8A-GTP, which also localizes to th ...[more]