Ontology highlight
ABSTRACT:
SUBMITTER: Sato T
PROVIDER: S-EPMC2596216 | biostudies-other | 2008 Dec
REPOSITORIES: biostudies-other
Sato Takahiro T Kurihara Yukiko Y Asai Rieko R Kawamura Yumiko Y Tonami Kazuo K Uchijima Yasunobu Y Heude Eglantine E Ekker Marc M Levi Giovanni G Kurihara Hiroki H
Proceedings of the National Academy of Sciences of the United States of America 20081118 48
Articulated jaws are highly conserved structures characteristic of gnathostome evolution. Epithelial-mesenchymal interactions within the first pharyngeal arch (PA1) instruct cephalic neural crest cells (CNCCs) to form the different skeletal elements of the jaws. The endothelin-1 (Edn1)/endothelin receptor type-A (Ednra)-->Dlx5/6-->Hand2 signaling pathway is necessary for lower jaw formation. Here, we show that the Edn1 signaling is sufficient for the conversion of the maxillary arch to mandibula ...[more]