Ontology highlight
ABSTRACT:
SUBMITTER: Yoshizaki T
PROVIDER: S-EPMC2643824 | biostudies-other | 2009 Mar
REPOSITORIES: biostudies-other
Yoshizaki Takeshi T Milne Jill C JC Imamura Takeshi T Schenk Simon S Sonoda Noriyuki N Babendure Jennie L JL Lu Juu-Chin JC Smith Jesse J JJ Jirousek Michael R MR Olefsky Jerrold M JM
Molecular and cellular biology 20081222 5
SIRT1 is a prominent member of a family of NAD(+)-dependent enzymes and affects a variety of cellular functions ranging from gene silencing, regulation of the cell cycle and apoptosis, to energy homeostasis. In mature adipocytes, SIRT1 triggers lipolysis and loss of fat content. However, the potential effects of SIRT1 on insulin signaling pathways are poorly understood. To assess this, we used RNA interference to knock down SIRT1 in 3T3-L1 adipocytes. SIRT1 depletion inhibited insulin-stimulated ...[more]