Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.
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ABSTRACT:
SUBMITTER: Hamilton-Williams EE
PROVIDER: S-EPMC2733871 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
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Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.
Hamilton-Williams Emma E EE Martinez Xavier X Clark Jan J Howlett Sarah S Hunter Kara M KM Rainbow Daniel B DB Wen Li L Shlomchik Mark J MJ Katz Jonathan D JD Beilhack Georg F GF Wicker Linda S LS Sherman Linda A LA
Journal of immunology (Baltimore, Md. : 1950) 20090710 3
In humans and NOD mice, defects in immune tolerance result in the spontaneous development of type-1-diabetes. Recent studies have ascribed a breakdown in tolerance to dysfunction in regulatory T cells that is secondary to reduced IL-2 production by T cells having the NOD diabetes susceptibility region insulin-dependent diabetes 3 (Idd3). In this study, we demonstrate a peripheral tolerance defect in the dendritic cells of NOD mice that is independent of regulatory T cells. NOD CD8 T cells specif ...[more]
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