Ontology highlight
ABSTRACT:
SUBMITTER: Suh HS
PROVIDER: S-EPMC2752833 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Suh Hyeon-Sook HS Zhao Meng-Liang ML Choi Namjong N Belbin Thomas J TJ Brosnan Celia F CF Lee Sunhee C SC
Virology 20090730 2
In the CNS, microglia are the primary targets of HIV infection. In this study, we investigated the effect of activation of the innate antiviral receptors TLR3 and TLR4 on HIV infection of primary human microglia, as well as microglial cell signaling and gene expression. Ligands for both TLR3 and TLR4 potently inhibited HIV replication in microglia through a pathway requiring IRF3. Surprisingly, a remarkably similar pattern of cell signaling and gene expression was observed in TLR3- and TLR4-acti ...[more]