Ontology highlight
ABSTRACT:
SUBMITTER: Hoehn KL
PROVIDER: S-EPMC2764908 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Hoehn Kyle L KL Salmon Adam B AB Hohnen-Behrens Cordula C Turner Nigel N Hoy Andrew J AJ Maghzal Ghassan J GJ Stocker Roland R Van Remmen Holly H Kraegen Edward W EW Cooney Greg J GJ Richardson Arlan R AR James David E DE
Proceedings of the National Academy of Sciences of the United States of America 20090930 42
We know a great deal about the cellular response to starvation via AMPK, but less is known about the reaction to nutrient excess. Insulin resistance may be an appropriate response to nutrient excess, but the cellular sensors that link these parameters remain poorly defined. In the present study we provide evidence that mitochondrial superoxide production is a common feature of many different models of insulin resistance in adipocytes, myotubes, and mice. In particular, insulin resistance was rap ...[more]