Ontology highlight
ABSTRACT:
SUBMITTER: Laurila JP
PROVIDER: S-EPMC2835086 | biostudies-other | 2009 Mar
REPOSITORIES: biostudies-other
Laurila Juha P JP Castellone Maria D MD Curcio Antonio A Laatikainen Lilja E LE Haaparanta-Solin Merja M Gronroos Tove J TJ Marjamaki Paivi P Martikainen Satu S Santoro Massimo M Laukkanen Mikko O MO
Molecular therapy : the journal of the American Society of Gene Therapy 20081223 3
Extracellular superoxide dismutase (SOD3) gene therapy has been shown to attenuate tissue damages and to improve the recovery of the tissue injuries, but the cellular events delivering the therapeutic response of the enzyme are not well defined. In the current work, we overexpressed SOD3 in rat hindlimb ischemia model to study the signal transduction and injury healing following the sod3 gene transfer. The data suggest a novel sod3 gene transfer-derived signal transduction cascade through Ras-Me ...[more]