Ontology highlight
ABSTRACT:
SUBMITTER: Stern E
PROVIDER: S-EPMC2838924 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Stern Eric E Vacic Aleksandar A Li Chao C Ishikawa Fumiaki N FN Zhou Chongwu C Reed Mark A MA Fahmy Tarek M TM
Small (Weinheim an der Bergstrasse, Germany) 20100101 2
Semiconducting nanowires are promising ultrasensitive, label-free sensors for small molecules, DNA, proteins, and cellular function. Nanowire field-effect transistors (FETs) function by sensing the charge of a bound molecule. However, solutions of physiological ionic strength compromise the detection of specific binding events due to ionic (Debye) screening. A general solution to this limitation with the development of a hybrid nanoelectronic enzyme-linked immunosorbent assay (ne-ELISA) that com ...[more]