Ontology highlight
ABSTRACT:
SUBMITTER: Das B
PROVIDER: S-EPMC2840090 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Das Bhabatosh B Bischerour Julien J Val Marie-Eve ME Barre François-Xavier FX
Proceedings of the National Academy of Sciences of the United States of America 20100121 9
Cholera toxin is encoded in the genome of CTXvarphi, a lysogenic filamentous phage of Vibrio cholerae. CTXvarphi variants contribute to the genetic diversity of cholera epidemic strains. It has been shown that the El Tor variant of CTXvarphi hijacks XerC and XerD, two host-encoded tyrosine recombinases that normally function to resolve chromosome dimers, to integrate at dif1, the dimer resolution site of the larger of the two V. cholerae chromosomes. However, the exact mechanism of integration o ...[more]