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Molecular mechanism of acquisition of the cholera toxin genes.


ABSTRACT: One of the major pathogenic determinants of Vibrio cholerae, the cholera toxin, is encoded in the genome of a filamentous phage, CTX?. CTX? makes use of the chromosome dimer resolution system of V. cholerae to integrate its single stranded genome into one, the other, or both V. cholerae chromosomes. Here, we review current knowledge about this smart integration process.

SUBMITTER: Das B 

PROVIDER: S-EPMC3089051 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Molecular mechanism of acquisition of the cholera toxin genes.

Das Bhabatosh B   Bischerour Julien J   Barre Francois-Xavier FX  

The Indian journal of medical research 20110201


One of the major pathogenic determinants of Vibrio cholerae, the cholera toxin, is encoded in the genome of a filamentous phage, CTXφ. CTXφ makes use of the chromosome dimer resolution system of V. cholerae to integrate its single stranded genome into one, the other, or both V. cholerae chromosomes. Here, we review current knowledge about this smart integration process. ...[more]

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