Ontology highlight
ABSTRACT:
SUBMITTER: Funk CD
PROVIDER: S-EPMC286962 | biostudies-other | 1989 Apr
REPOSITORIES: biostudies-other
Funk C D CD Hoshiko S S Matsumoto T T Rdmark O O Samuelsson B B
Proceedings of the National Academy of Sciences of the United States of America 19890401 8
The gene for human 5-lipoxygenase has been isolated from three different bacteriophage genomic libraries and a genomic cosmid library. The gene spans greater than 82 kilobases and consists of 14 exons. The size range for the exons is 82-613 base pairs, whereas that for the introns is approximately 200 bp to greater than 26 kb. A major site of transcription initiation in leukocytes was mapped to a thymidine residue 65 base pairs upstream of the ATG initiation codon by nuclease S1 protection and p ...[more]