Calcium channel activity of purified human synexin and structure of the human synexin gene.
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ABSTRACT:
SUBMITTER: Burns AL
PROVIDER: S-EPMC287228 | biostudies-other | 1989 May
REPOSITORIES: biostudies-other
Publications
Calcium channel activity of purified human synexin and structure of the human synexin gene.
Burns A L AL Magendzo K K Shirvan A A Srivastava M M Rojas E E Alijani M R MR Pollard H B HB
Proceedings of the National Academy of Sciences of the United States of America 19890501 10
Synexin is a calcium-dependent membrane binding protein that not only fuses membranes but also acts as a voltage-dependent calcium channel. We have isolated and sequenced a set of overlapping cDNA clones for human synexin. The derived amino acid sequence of synexin reveals strong homology in the C-terminal domain with a previously identified class of calcium-dependent membrane binding proteins. These include endonexin II, lipocortin I, calpactin I heavy chain (p36), protein II, and calelectrin 6 ...[more]
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