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Stereochemical and skeletal diversity arising from amino propargylic alcohols.

ABSTRACT: An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis.

SUBMITTER: Pizzirani D 

PROVIDER: S-EPMC2883853 | biostudies-other | 2010 Jun

REPOSITORIES: biostudies-other

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Stereochemical and skeletal diversity arising from amino propargylic alcohols.

Pizzirani Daniela D   Kaya Taner T   Clemons Paul A PA   Schreiber Stuart L SL  

Organic letters 20100601 12

An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis. ...[more]

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