Ontology highlight
ABSTRACT:
SUBMITTER: Sello JK
PROVIDER: S-EPMC4134662 | biostudies-other | 2003 Oct
REPOSITORIES: biostudies-other
Organic letters 20031001 22
[reaction: see text]. Substrates having appendages that pre-encode skeletal information (sigma-elements) can be converted into products having distinct skeletons using a common set of reaction conditions. The sequential use of the Ugi 4CC-IMDA reaction, followed by allylation, hydrolysis, and acylation of a chiral amino alcohol appendage (sigma-element), leads to substrates for a ROM/RCM or RCM reaction. The stereochemistry of the sigma-element and not its constitution controls the outcome of th ...[more]