Ontology highlight
ABSTRACT:
SUBMITTER: Arbuckle MI
PROVIDER: S-EPMC2892321 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
Arbuckle Margaret I MI Komiyama Noboru H NH Delaney Ada A Coba Marcelo M Garry Emer M EM Rosie Roberta R Allchorne Andrew J AJ Forsyth Lynsey H LH Bence Matthew M Carlisle Holly J HJ O'Dell Thomas J TJ Mitchell Rory R Fleetwood-Walker Susan M SM Grant Seth G N SG
EMBO reports 20100514 6
Sensitization to inflammatory pain is a pathological form of neuronal plasticity that is poorly understood and treated. Here we examine the role of the SH3 domain of postsynaptic density 95 (PSD95) by using mice that carry a single amino-acid substitution in the polyproline-binding site. Testing multiple forms of plasticity we found sensitization to inflammation was specifically attenuated. The inflammatory response required recruitment of phosphatidylinositol-3-kinase-C2alpha to the SH3-binding ...[more]