Dataset Information
Synthesis of the bis-tetrahydropyran core of amphidinol 3.
Ontology highlight
ABSTRACT:
SUBMITTER: Crimmins MT
PROVIDER: S-EPMC2929927 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
Publications
Synthesis of the bis-tetrahydropyran core of amphidinol 3.
Organic letters 20100901 17
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 is reported. A common intermediate was synthesized from d-tartaric acid utilizing an asymmetric glycolate alkylation/ring-closing metathesis sequence to construct the THP rings. Differential elaboration of the common intermediate allowed the synthesis of two distinct coupling partners which were joined through a modified Horner-Wadsworth-Emmons olefination to provide the bis-tetrahydropyran core. ...[more]
