Ontology highlight
ABSTRACT:
SUBMITTER: Haller O
PROVIDER: S-EPMC2937866 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20100610 37
The interferon-inducible MxA GTPase is a key mediator of cell-autonomous innate immunity against a broad range of viruses such as influenza and bunyaviruses. MxA shares a similar domain structure with the dynamin superfamily of mechanochemical enzymes, including an N-terminal GTPase domain, a central middle domain, and a C-terminal GTPase effector domain. Recently, crystal structures of a GTPase domain dimer of dynamin 1 and of the oligomerized stalk of MxA (built by the middle and GTPase effect ...[more]