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Structure of spliceosomal ribonucleoproteins.

ABSTRACT: Splicing of the precursors of eukaryotic mRNA and some non-coding RNAs is catalyzed by the 'spliceosome', which comprises five RNA-protein complexes (small nuclear ribonucleoproteins, or snRNPs) that assemble in an ordered manner onto precursor-mRNAs. Much progress has been made in determining the gross morphology of spliceosomal assembly intermediates. Recently, the first crystal structure of a spliceosomal snRNP has provided significant insight into assembly and architecture of spliceosomal snRNPs in general and the structure-function relationship of human U1 snRNP in particular.

SUBMITTER: Krummel DA

PROVIDER: S-EPMC2950031 | biostudies-other | 2010 May

REPOSITORIES: biostudies-other

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Structure of spliceosomal ribonucleoproteins.

Krummel Daniel Aaron Pomeranz DA Nagai Kiyoshi K Oubridge Chris C

F1000 biology reports 20100524

Splicing of the precursors of eukaryotic mRNA and some non-coding RNAs is catalyzed by the 'spliceosome', which comprises five RNA-protein complexes (small nuclear ribonucleoproteins, or snRNPs) that assemble in an ordered manner onto precursor-mRNAs. Much progress has been made in determining the gross morphology of spliceosomal assembly intermediates. Recently, the first crystal structure of a spliceosomal snRNP has provided significant insight into assembly and architecture of spliceosomal sn ...[more]

PMID: 20948795

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