Ontology highlight
ABSTRACT:
SUBMITTER: Schmitzova J
PROVIDER: S-EPMC3597571 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Schmitzová Jana J Pena Vladimir V
RNA biology 20121012 11
Pre-mRNA splicing occurs in two chemical steps that are catalyzed by a large, dynamic RNA-protein complex called the spliceosome. Initially assembled in a catalytically inactive form, the spliceosome undergoes massive compositional and conformational remodeling, through which disparate RNA elements are re-configured and juxtaposed into a functional catalytic center. The intricate construction of the catalytic center requires the assistance of spliceosomal proteins. Recent structure-function anal ...[more]