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Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling.

ABSTRACT: OBJECTIVE: We have previously shown that overnight fasted women have higher insulin-stimulated whole body and leg glucose uptake despite a higher intramyocellular triacylglycerol concentration than men. Women also express higher muscle mRNA levels of proteins related to lipid metabolism than men. We therefore hypothesized that women would be less prone to lipid-induced insulin resistance. RESEARCH DESIGN AND METHODS: Insulin sensitivity of whole-body and leg glucose disposal was studied in 16 young well-matched healthy men and women infused with intralipid or saline for 7 h. Muscle biopsies were obtained before and during a euglycemic-hyperinsulinemic clamp (1.42 mU · kg?¹ · min?¹). RESULTS: Intralipid infusion reduced whole-body glucose infusion rate by 26% in women and 38% in men (P < 0.05), and insulin-stimulated leg glucose uptake was reduced significantly less in women (45%) than men (60%) after intralipid infusion. Hepatic glucose production was decreased during the clamp similarly in women and men irrespective of intralipid infusion. Intralipid did not impair insulin or AMPK signaling in muscle and subcutaneous fat, did not cause accumulation of muscle lipid intermediates, and did not impair insulin-stimulated glycogen synthase activity in muscle or increase plasma concentrations of inflammatory cytokines. In vitro glucose transport in giant sarcolemmal vesicles was not decreased by acute exposure to fatty acids. Leg lactate release was increased and respiratory exchange ratio was decreased by intralipid. CONCLUSIONS: Intralipid infusion causes less insulin resistance of muscle glucose uptake in women than in men. This insulin resistance is not due to decreased canonical insulin signaling, accumulation of lipid intermediates, inflammation, or direct inhibition of GLUT activity. Rather, a higher leg lactate release and lower glucose oxidation with intralipid infusion may suggest a metabolic feedback regulation of glucose metabolism.

SUBMITTER: Hoeg LD

PROVIDER: S-EPMC3012198 | biostudies-other | 2011 Jan

REPOSITORIES: biostudies-other

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Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling.

Høeg Louise D LD Sjøberg Kim A KA Jeppesen Jacob J Jensen Thomas E TE Frøsig Christian C Birk Jesper B JB Bisiani Bruno B Hiscock Natalie N Pilegaard Henriette H Wojtaszewski Jørgen F P JF Richter Erik A EA Kiens Bente B

Diabetes 20101018 1

<h4>Objective</h4>We have previously shown that overnight fasted women have higher insulin-stimulated whole body and leg glucose uptake despite a higher intramyocellular triacylglycerol concentration than men. Women also express higher muscle mRNA levels of proteins related to lipid metabolism than men. We therefore hypothesized that women would be less prone to lipid-induced insulin resistance.<h4>Research design and methods</h4>Insulin sensitivity of whole-body and leg glucose disposal was stu ...[more]

PMID: 20956497

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Project description:In the present research, we applied a goal-congruity perspective - the proposition that men and women seek out roles that afford their internalized values (Diekman et al., 2017) - to better understand the degree to which careers in healthcare, early education, and domestic roles (HEED; Croft et al., 2015) are devalued in society. Our first goal was to test the hypothesis that men, relative to women, are less interested in pursuing HEED careers in part because they are less likely than women to endorse communal values. A second, more novel goal was to extend goal congruity theory to examine whether gender differences in communal values also predict the belief that HEED careers add worth to society and are deserving of higher salaries. In three studies of undergraduate students (total N = 979), we tested the predictive role of communal values (i.e., a focus on caring for others), as distinct from agentic values (i.e., a focus on status, competition, and wealth; Bakan, 1966). Consistent with goal congruity theory, Studies 1 and 2 revealed that men's lower interest in adopting HEED careers, such as nursing and elementary education, was partially mediated by men's (compared to women's) lower communal values. Extending the theory, all three studies also documented a general tendency to see HEED as having relatively lower worth to society compared to STEM careers. As expected, communal values predicted perceiving higher societal worth in HEED careers, as well as supporting increases in HEED salaries. Thus, gender differences in communal values accounted for men's (compared to women's) tendency to perceive HEED careers as having less societal worth and less deserving of salary increases. In turn, gender differences in perceived societal worth of HEED itself predicted men's relatively lower interest in pursuing HEED careers. In no instance, did agentic values better explain the gender difference in HEED interest or perceived worth. These findings have important implications for how we understand the value that society places on occupations typically occupied by women versus men.

Dataset Information

Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling.

Publications

Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling.

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