Ontology highlight
ABSTRACT:
SUBMITTER: Carlson JC
PROVIDER: S-EPMC3019614 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Chembiochem : a European journal of chemical biology 20100301 4
The structurally intriguing bicyclic ketal moiety of tirandamycin is common to several acyl-tetramic acid antibiotics, and is a key determinant of biological activity. We have identified the tirandamycin biosynthetic gene cluster from the environmental marine isolate Streptomyces sp. 307-9, thus providing the first genetic insight into the biosynthesis of this natural product scaffold. Sequence analysis revealed a hybrid polyketide synthase-nonribosomal peptide synthetase gene cluster with a col ...[more]