Ontology highlight
ABSTRACT:
SUBMITTER: Mohammed HS
PROVIDER: S-EPMC3166489 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Artificial DNA, PNA & XNA 20110401 2
Two symmetrical cyanine dyes based on benzothiazole heterocycles and a trimethine bridge were found to bind to a parallel-stranded DNA guanine quadruplex based on the MYC oncogene promoter sequence with high nanomolar affinity and 1:1 stoichiometry. The dyes exhibited substantial fluorescence enhancements upon binding. In the presence of homologous guanine-rich peptide nucleic acid oligomers, PNA-DNA heteroquadruplexes were formed. The dyes retained their ability to bind to the heteroquadruplexe ...[more]