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The p75 receptor mediates axon growth inhibition through an association with PIR-B.

ABSTRACT: The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand binding. In addition, p75 was required for activation of Src homology 2-containing protein tyrosine phosphatase (SHP), which is induced by MAG binding to PIR-B. Mice carrying a mutation in the p75 gene showed promotion of axonal regeneration after optic nerve injury. Thus, our results indicate that p75 has a critical role in axon growth inhibition in specific neuronal tracts.

SUBMITTER: Fujita Y

PROVIDER: S-EPMC3186903 | biostudies-other | 2011

REPOSITORIES: biostudies-other

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The p75 receptor mediates axon growth inhibition through an association with PIR-B.

Fujita Y Y Takashima R R Endo S S Takai T T Yamashita T T

Cell death & disease 20110901

The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand binding. In addition, p75 was required for activation of Src homology 2-containing protein tyrosine phosphatase (SHP), which is induced by MAG binding to PIR-B. Mice carrying a mutation ...[more]

PMID: 21881600

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