Ontology highlight
ABSTRACT:
SUBMITTER: Strand M
PROVIDER: S-EPMC3203805 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Strand Marie M Micchelli Craig A CA
Proceedings of the National Academy of Sciences of the United States of America 20111007 43
The adult Drosophila copper cell region or "stomach" is a highly acidic compartment of the midgut with pH < 3. In this region, a specialized group of acid-secreting cells similar to mammalian gastric parietal cells has been identified by a unique ultrastructure and by copper-metallothionein fluorescence. However, the homeostatic mechanism maintaining the acid-secreting "copper cells" of the adult midgut has not been examined. Here, we combine cell lineage tracing and genetic analysis to investig ...[more]