Ontology highlight
ABSTRACT:
SUBMITTER: Woydziak ZR
PROVIDER: S-EPMC3256751 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
The Journal of organic chemistry 20111123 1
Fluorination of fluorophores can substantially enhance their photostability and improve spectroscopic properties. To facilitate access to fluorinated fluorophores, bis(2,4,5-trifluorophenyl)methanone was synthesized by treatment of 2,4,5-trifluorobenzaldehyde with a Grignard reagent derived from 1-bromo-2,4,5-trifluorobenzene, followed by oxidation of the resulting benzyl alcohol. This hexafluorobenzophenone was subjected to sequential nucleophilic aromatic substitution reactions, first at one o ...[more]