Ontology highlight
ABSTRACT:
SUBMITTER: De Silva A
PROVIDER: S-EPMC3267038 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
De Silva Akila A Salem Victoria V Long Christopher J CJ Makwana Aidan A Newbould Rexford D RD Rabiner Eugenii A EA Ghatei Mohammad A MA Bloom Stephen R SR Matthews Paul M PM Beaver John D JD Dhillo Waljit S WS
Cell metabolism 20111013 5
Obesity is a major public health issue worldwide. Understanding how the brain controls appetite offers promising inroads toward new therapies for obesity. Peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) are coreleased postprandially and reduce appetite and inhibit food intake when administered to humans. However, the effects of GLP-1 and the ways in which PYY and GLP-1 act together to modulate brain activity in humans are unknown. Here, we have used functional MRI to determine these effects ...[more]