Ontology highlight
ABSTRACT:
SUBMITTER: Tan X
PROVIDER: S-EPMC3271875 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Tan Xu X Lu Zhi John ZJ Gao Geng G Xu Qikai Q Hu Long L Fellmann Christof C Li Mamie Z MZ Qu Hongjing H Lowe Scott W SW Hannon Gregory J GJ Elledge Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20120104 3
shRNAs can trigger effective silencing of gene expression in mammalian cells, thereby providing powerful tools for genetic studies, as well as potential therapeutic strategies. Specific shRNAs can interfere with the replication of pathogenic viruses and are currently being tested as antiviral therapies in clinical trials. However, this effort is hindered by our inability to systematically and accurately identify potent shRNAs for viral genomes. Here we apply a recently developed highly parallel ...[more]