Ontology highlight
ABSTRACT:
SUBMITTER: Vesikansa A
PROVIDER: S-EPMC3298885 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Vesikansa Aino A Sakha Prasanna P Kuja-Panula Juha J Molchanova Svetlana S Rivera Claudio C Huttunen Henri J HJ Rauvala Heikki H Taira Tomi T Lauri Sari E SE
Scientific reports 20120312
Kainate-type glutamate receptors (KARs) regulate synaptic transmission and neuronal excitability via multiple mechanisms, depending on their subunit composition. Presynaptic KARs tonically depress glutamatergic transmission during restricted period of synapse development; however, the molecular basis behind this effect is unknown. Here, we show that the developmental and cell-type specific expression pattern of a KAR subunit splice variant, GluK1c, corresponds to the immature-type KAR activity i ...[more]