Ontology highlight
ABSTRACT:
SUBMITTER: Nehlin JO
PROVIDER: S-EPMC334331 | biostudies-other | 1992 Oct
REPOSITORIES: biostudies-other
Nehlin J O JO Carlberg M M Ronne H H
Nucleic acids research 19921001 20
We have cloned a yeast gene, SKO1, which in high copy number suppresses lethal overexpression of cAMP-dependent protein kinase. SKO1 encodes a bZIP protein that binds to the CRE motif, TGACGTCA. We found that SKO1 also binds to a CRE-like site in SUC2, a yeast gene encoding invertase which is under positive control by cAMP. A disruption of the SKO1 gene causes a partial derepression of SUC2, indicating that SKO1 is a negative regulator of the SUC2 gene. SKO1 interacts positively with MIG1, a zin ...[more]