Ontology highlight
ABSTRACT:
SUBMITTER: Carlier VA
PROVIDER: S-EPMC3467281 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Carlier Vincent A VA VanderElst Luc L Janssens Wim W Jacquemin Marc G MG Saint-Remy Jean-Marie R JM
PloS one 20121009 10
The nature of MHC class II-binding epitopes not only determines the specificity of T cell responses, but may also alter effector cell functions. Cytolytic CD4+ T cells have been observed primarily in anti-viral responses, but very little is known about the conditions under which they can be elicited. Their potential as regulators of immune responses, however, deserves investigations. We describe here that inclusion of a thiol-disulfide oxidoreductase motif within flanking residues of class II-re ...[more]