Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC3498831 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Wang Zhenxun Z Jeon Hyun Yong HY Rigo Frank F Bennett C Frank CF Krainer Adrian R AR
Open biology 20121001 10
Alternative splicing of the pyruvate kinase M gene involves a choice between mutually exclusive exons 9 and 10. Use of exon 10 to generate the M2 isoform is crucial for aerobic glycolysis (the Warburg effect) and tumour growth. We previously demonstrated that splicing enhancer elements that activate exon 10 are mainly found in exon 10 itself, and deleting or mutating these elements increases the inclusion of exon 9 in cancer cells. To systematically search for new enhancer elements in exon 10 an ...[more]